Genomics
Review pages 20 and 21 in the required textbook. By the time you get to this topic you should have seen issues related to genomics and chronic diseases in many of the daily lists of research results you have been getting. Consider some of the recommendations made in these papers that illustrate the state of the art and changes we may see in the next few years. What have you learned from the presentations during the course and from invited lecturers on social determinants of health and whether these includes genomics? To illustrate your appreciation for the issue bring with you at least two papers/URLS that indicate how new genetic information may help prevent or delay onset of the conditions you presented during the course, positive or negative. Be prepared to discuss some translational research that could be used to improve population interventions for these conditions..
Review the CDC Home Page on Genomics. Pay special attention to the section on genomics testing and translational application.
Consider the problem of accessing and improving family histories to prevent chronic disease in future generations. Also review the weekly updates with special attention to this week's update..
Look at the recommendations of the EGAPP working group and heart disease. Publication date Oct. 2010.
Use the web to look for new advances in genetics application to health care. Can you find any examples where genetics has made a difference? Look at this recent article from the "Scientist" magazine, And this one from the journal Science.
Thinking about our readings on health equity is it also a problem in the field of genetics?
Additional Readings for this session
Translating genomics into improved health care
JAMA - New Limbs
What Is Epigenetics?
New Anti-HIV Gene Therapy Makes T-Cells Resistant to HIV Infection
Genomics & Perinatal care. Why should this be important to reducing the impact of chronic diseases? Note the institution responsible for this Review Article.
Many of the chronic diseases that affect us are associated with autoimmunity, read this recent article from New England medical Journal.
This current set of readings covers some of the controversies in the current field of genetics:
Genome wide A
sociation studies
Genes linked to low birth weight
Targeting DNA
The 1000 genome project
IOM Genetics Part1
IPM Genetics Pt II
Modeling human disease
Genomic prediction
The epigenome
Will the revolution in genetics improve healthcare
Erik's PowerPoint
.Reference Material:
The Value of Genetic and Genomic Technologies: Workshop Summary (IOM Booklet)
New Approach to Mendelian Disorders - NEMJ Review Paper.
Look at these short videos from Science Number#1 and Science Magazine#2
Genetics Home Reference provides consumer-friendly information about the effects of genetic variations on human health.
Health Care Costs & Chronic Disease
Go to Kaiser FF educational brief on topic. Read the Brief, review the associated supporting materials and be prepared to discuss the questions at the end of the briefing. You may find some useful discussions at the Center for System Change, There is good reference material attached as well.
US Budget - FY 2012
Reference: National expenditure data
GDP for USA
Rising Health Care Costs
IOM study on Health Care Change (scan only, too,much to read in depth, unless you want to).
CBO Testimony on Controlling Health Care Costs, 2008, in particular Pages 4, 7, 10, 11, 16, an d 18 thru 20.
This PowerPoint set is a little old but the data is similarly problematic today.
Hastings Center Report. You might want to dip into a collection of papers from the HC on the topicx.
Medical Technology & costs